Focused Attention Training Project. Email: research@focusedattention.org Phone: 617-495-9985
We use functional MRI to probe the neural mechanisms of attention and how it may change after training. Attention is a key component of many cognitive abilities including visual perception, cognitive control, and memory. The amount and quality of your sleep can have a marked influence on your attentional abilities. Improving focused and sustained attention can you help better filter out distractions and improve productivity. Research shows that cognitive training can produce lasting changes in neural circuits involved in attention. The Boston VA Medical Center. Home of the Boston Attention and Learning Lab. The campus of University of California, Berkeley. Home to the VanVleet Lab.
We use functional MRI to probe the neural architecture of attention as well as how this may be disrupted in disordered populations and how it may change after cognitive training.
We are a group of neuroscientists and clinicians from Harvard Medical School, the University of California, Berkeley, Veterans Affairs Hospitals (in Martinez, CA, and Boston, MA), and the Brain Plasticity Institute who are interested in how people pay attention and also the potential of enhancing attention abilities through computer-based cognitive training. We use a variety of methods to measure peoples' attention abilities ranging from simple questionnaires about everyday 'lapses of attention' to computer-based tests of spatial attention and memory to sophisticated neuroimaging techniques such as functional MRI and electroencephalography. Drawing from a variety of disciplines including cognitive neuroscience, neurorehabilitation, and neuropharmacology, we ultimately seek to develop effective computer-based attention training programs that can improve peoples' quality of life.

Importance
The ability to focus and sustain attention is important for staying on task amongst distractions and is fundamental to more complex processes such as memory and decision-making. Deficits in focusing and sustaining attention are quite common and in day-to-day life can manifest as lapses of attention while driving (such as missing your exit), not remembering a new acquaintance's name, or difficulty completing complex tasks. More serious deficits can lead to an increased propensity for accidents (i.e. car accidents or falls) and can make it difficult to maintain employment.

Attention and the brain
The optimal ability to sustain and focus attention occurs during a state of medium arousal (not too drowsy or too anxious) and when you are highly engaged by your current task. Sustained attention and focus also requires repeatedly disengaging from distractions and redirecting focus to back to the current task. Together, these processes have shown to rely on a broad network of brain regions that include the locus coeruleus in the brainstem as well as regions in the frontal and parietal lobes. The locus coeruleus makes norepinephrine, a neurotransmitter intimately involved in arousal, and supplies it to the entire brain. Frontal and parietal brain regions help to sustain attention and filter distractions and send feedback to the locus coeruleus. The back-and-forth between frontal and parietal brain regions and the locus coeruleus is a key to sustained attention and focus.

People with attention difficulties
Difficulty focusing and sustaining attention is prevalent in people with ADHD, age-related cognitive decline, traumatic brain injury, and post-traumatic stress disorder (PTSD). These deficits may be from damage to frontal and parietal lobe brain regions, too much or too little norepinephrine released from the locus coeruleus, or poor communication between the locus coeruleus and frontal and parietal brain regions. These deficits may be reflected in frequent lapses of attention in daily life, which may range from difficulty successfully accomplishing a complex task to falls (particularly in the aging population) to an increased risk of car accidents.

Past research
While there have been several drug and behavioral treatments aimed at improving focus and sustained attention, they have shown mixed results. For example, drug treatments (e.g. Adderall, Ritalin, Provigil) can be useful for treating alertness and sustained attention impairments, but the results are somewhat inconsistent and may cause unwanted side effects such as anxiety, headache, and nausea. A more benign and cost effective approach to improving alertness is focused attention meditation. Focused attention meditation involves attending to one object or sensation for a prolonged period of time. After several months of focused attention meditation, researchers have found improved sustained attention and increased attentional stability. Though these results are promising, for many individuals, focused attention meditation may be too boring or difficult without supervision.

Rationale of the Current Study
We have developed a new computer-based treatment method that exercises two aspects of attention at one time: tonic attention and phasic attention. Tonic attention refers to the ongoing state of readiness that changes on the order of minutes to hours. In contrast, phasic attention is the rapid change in attention due to any briefly engaging event. Recent evidence from our laboratory shows that training tonic and phasic attention in one task may be critical to producing strong and lasting improvements in focusing and sustaining attention. The idea is that through performing this task over a prolonged period of time each day (36 minutes), you will practice being in a relaxed and ready state of attention that will carry over beyond training and allow you to better focus and sustain your attention in your daily life.

What you will be doing
In this study, you will take several computer-based tests in order to measure your attention abilities as well as fill out questionnaires about how often you have lapses of attention. You may also be asked to fill out a daily attention diary for five days. Next you will be asked to perform the attention training procedure for several days. There are multiple versions of attention training, but basically you will be continuously shown visual scenes and are to respond to some scenes in one way (such as pressing the spacebar) while responding to other scenes differently (such as hitting the spacebar). After completing the training, to measure potential improvements, you will take the computer-based tests again and may be asked to again fill out a daily attention diary.

Boston Attention and Learning Lab Brain Plasticity Institute: VanVleet Lab
If you live near the Boston area and would like to participate in one of our attention training studies, please contact Roger Mercado (rmercado@nmr.mgh.harvard.edu). Or, if you live near the San Francisco Bay area and would like to participate in one of our attention training studies, please contact Christina Marini (christina.marini@brainplasticity.com, 415-230-3741)